LIFECYCLE OF PLASMODIUM IN MAN

PLASMODIUM LIFECYCLE IN MAN ;1.Plasmodium completes its life cycle in two hosts
2.female anopheles mosquito is definitive host , man is intermediate host
3.In man asexual lifecycle occurs
4.In man plasmodium completes its lifecycle in two stages. They are
a)Exoerythrocytic stage b) Erythrocytic stage
EXOERYTHROCYTIC STAGE: In this stage two generations are formed. They are preerythrocytic generations and exoerythrocytic generations
PREERYTHROCYTIC GENERATIONS :
1.When mosquito bite humanbeing the sporozoite stage of plasmodium enters into man
2.The sporozoite stage is infective stage of plasmodium to man
3.Sporozoites enters into liver cells from blood stream
4.After entering into the liver cells sporozoites are transformed into trophozoites in livercells
5.The nucleus of the trophozoite undergoes multiplications to become schizont
6.Within 8 days,cytoplasm divides and large number of cryptozoites are released into the liver sinusoids
7.These cryptozoites may either enter into RBC or into another livercells.
EXOERYTHROCYTIC GENERATIONS:
1.When the cryptozoites enter into livercells ,they transform into trophozoites in livercells
2.The nucleus of the trophozoite divides several times and become a multinucleate schizont
3.Then cytoplasm divides and large number of metacryptozoites are released into the sinusoids of liver
4.Two types of metacryptozoits are present ,they are a)Macrometacryptozoites and b)Micrometacryptozoites.
5.Macrometacryptomerozoite enter into fresh liver cells and micrometacryptozoites into RBC
ERYTHROCYTIC STAGE (GOLGI CYCLE) :
1.Micrometacryptozoites or cryptozoites enter into RBC and become trophozoites
2.The vacuole of the trophozoite increases in size and pushes the cytoplasm and nucleus to periphery
3.In this stage the parasite appears like a ring hence it is called signet ring stage
4.After signet ring stage plasmodium develops pseudopodia and appears like amoeba , hence this stage is called amoeboid stage
5.Later amoeboid stage develops into schizont
6.Again in this schizont multiplications take place and merozoites are formed
7.Merozoites are released from RBC along with haemozoin granules.
8.Due to this haemozoin granules the symptoms of malaria are seen